The Applikon BioSep system is a unique, cell retention device for high-density perfusion processes. Using high frequency resonant ultrasonic waves to separate cells instead of a physical mesh or membrane, it offers all the benefits of traditional devices but without their inherent problems and limitations. The BioSep, based on the technology of acoustic resonance, is a non fouling / non clogging retention system. The BioSep can be applied in both R&D (max. 1 L/day), process development and on production scale (1000 L/day).

• Proven under cGMP conditions
• Easy to install and to operate
• Can be used in combination with any brand of bioreactor
• Long term cultivation possible (> 6 months)
• No fouling or blocking
• No damage to the cells
• High separation efficiency (> 95%)
  

• Cell cultures
• Perfusion cultures